Drug Testing Locations in California

Accredited Drug Testing has 1,191 drug testing centers in 1,930 CA cities.

Please select a city from the list below to find drug test centers in California.

Why California Employers Choose Our Drug Testing Services

California employers benefit significantly from our drug testing services, strategically positioned in 1,191 test centers across 1,932 cities. This expansive network ensures seamless access to testing facilities, enabling businesses to uphold strict workplace safety and compliance standards efficiently.

Our services assist employers in identifying drug-related issues before they impact workplace productivity and safety. By opting for our comprehensive solutions, businesses can effectively manage risks, reduce liability, and foster a healthier work environment.

In addition to promoting safety, our testing services enhance trust and reliability among employees and clients. Implementing regular drug testing underscores a company's commitment to maintaining high operational standards while safeguarding its reputation in the industry.

Employers also find value in the flexibility and customization of our testing packages. By tailoring services to specific business needs, we provide a cost-effective solution that aligns with varying sizes and types of industries, supporting operational goals without compromising on quality or speed.

California Drug Free Workplace Programs

California has taken significant steps to promote a safe and healthy work environment, emphasizing the importance of a drug-free workforce. While the state does not operate under a unified Drug Free Workplace Program, it encourages employers to maintain their own policies in line with federal guidelines. The California Drug-Free Workplace Act of 1990 obligates state contractors and grantees to adhere to specific standards, fostering environments where substance abuse is minimized.

Employers are encouraged to develop comprehensive substance abuse policies, providing resources and support for employees in need. These measures not only enhance productivity but also contribute to a positive workplace culture. By advocating awareness and offering assistance, California strives to balance employee rights with the necessity of maintaining a secure and drug-free workplace.

How does the body eliminate Drugs

Drug elimination is the sum of the processes of removing an administered drug from the body. In the pharmacokinetic ADME scheme (absorption, distribution, metabolism, and excretion), it is frequently considered to encompass both metabolism and excretion. Hydrophobic drugs, to be excreted, must undergo metabolic modification making them more polar. Hydrophilic drugs, on the other hand, can undergo excretion directly, without the need for metabolic changes to their molecular structures.

Although many sites of metabolism and excretion exist, the chief organ of metabolism is the liver, while the organ primarily tasked with excretion is the kidney. Any significant dysfunction in either organ can result in the accumulation of the drug or its metabolites in toxic concentrations.

A variety of other factors impact elimination — intrinsic drug properties, such as polarity, size, or pKa. Also other factors include genetic variation among individuals, disease states affecting other organs, and pathways involved in the way the drug distributes through the body, such as first-pass metabolism.

Issues of Concern

Drug elimination is the removal of an administered drug from the body. It is accomplished in two ways, either by excretion of an unmetabolized drug in its intact form or by metabolic biotransformation followed by excretion. While excretion is primarily carried out by the kidneys, other organ systems are involved as well. Similarly, the liver is the primary site of biotransformation, yet extrahepatic metabolism takes place in a variety of organ systems affecting multiple drugs.

Given the multiple organ systems and the variety of metabolic transformations present, drug elimination can entail a significant degree of complexity. Hydrophilic drugs are typically directly excreted by the kidneys, while hydrophobic drugs undergo biotransformation before excretion. The purpose here is twofold – biotransformation serves both detoxify the exogenous substances as well as to increase their hydrophilicity, ensuring their elimination via the kidneys.

Two broad metabolic pathways of hepatic drug transformation exist. Phase I is the direct modification of the target molecule, whereas phase II entails conjugation of the target to a polar molecule of low molecular weight. Phase I prepare the drug to enter phase II, but single-phase metabolism also exists.

Phase I involves oxidation, reduction, and hydrolysis of the exogenous molecule. These reactions are accomplished by hepatic microsomal enzymes, which reside in the smooth endoplasmic reticulum of the hepatocytes. Best known among them is the cytochrome P450 system, whose enzymes are predominantly involved in oxidative metabolism. Within the cytochrome P450 family (CYP), the enzyme responsible for the metabolism of more than 50% of existing drugs is the CYP3A4. Its activity encompasses various classes of medications, including opioids, immunosuppressants, antihistamines, and benzodiazepines. The enzymes can also be induced or inhibited by a variety of substances they interact with, including pharmaceuticals. The increase in metabolic activity with CYP induction results in a diminished activity of drugs targeted by that particular isoform. Conversely, CYP inhibition will result in increased drug plasma concentration, potentially leading toxicity. The CYP3A4 is induced by phenytoin, phenobarbital, and St. John's wort, while diltiazem, erythromycin, and grapefruit inhibit it. Caution is, therefore, necessary when administering CYP3A4-metabolized drugs in the presence of any of the inhibitors or inducers.

Phase II consists of covalent bonding of polar groups to nonpolar molecules to render them water-soluble and allow renal or biliary excretion. Target molecules enter phase II directly or via initial processing through phase I. A variety of polar adjuncts is transferred, including amino acids, glucuronic acid, glutathione, acetate, and sulfate. Glucuronidation is one of the major pathways of phase II biotransformation. The UDP-glucuronosyltransferase (UGT) enzyme family performs this activity. Typically, glucuronide derivatives possess less or no activity of the original drug, but in some cases, pharmacologically active compounds result. Morphine-6-glucuronide is a phase II metabolite of morphine with significant analgesic activity. As with the CYP enzymes, inducers, and inhibitors of phase II, enzymes exist and may influence the efficacy of drugs that rely on conjugation before excretion.

The first-pass effect is a feature of hepatic metabolism that also plays a role in the elimination of multiple drugs. Here, the enteric consumed drugs are exposed directly to the liver via the portal vein, where they undergo biotransformation before entering the systemic circulation. This activity reduces the bioavailability and needs to be factored into the dose administered to the patient. Intravenously administered drugs are not subject to the first-pass effect.

Extrahepatic drug metabolism takes place in the GI tract, kidneys, lungs, plasma, and skin.

Renal excretion completes the process of elimination that begins in the liver. Polar drugs or their metabolites get filtered in the kidneys and typically do not undergo reabsorption. They subsequently get excreted in the urine. Urinary pH has a significant impact on excretion, as drug ionization changes depending on the alkaline or acidic environment. Increased excretion occurs with weakly acidic drugs in basic urine and weakly basic drugs in acidic urine.

Excretion in the bile is another significant form of drug elimination. The liver can actively secrete ionized drugs with a molecular weight greater than 300 g/mol into bile, from where they reach the digestive tract and are either eliminated in feces or reabsorbed as part of the enterohepatic cycle.

Other pathways of excretion include the lungs, breast milk, sweat, saliva, and tears

Mobile/On-Site Drug Testing

If you're an employer needing to test 25 or more employees and looking to save time and money, we offer mobile on-site drug testing where we come to you. Call us today for more information.

California Laws on Drugs

California enforces strict regulations on controlled substances, emphasizing penalties for the possession, distribution, or manufacture of illegal drugs. Penalties vary from fines to imprisonment, based on the drug schedule and quantity involved. Legal frameworks are in place to manage the abuse and illegal trafficking, while aiming to decrease illegal drug activities through stringent law enforcement practices.

For prescription drugs, California regulates their distribution and usage through rigid licensing laws and prescription guidelines to prevent misuse. The state mandates that healthcare professionals adhere to prescribed standards for dispensing controlled medications, to ensure they are used safely and responsibly within medical contexts, to combat prescription drug abuse effectively.

California Laws on Marijuana

In California, recreational marijuana use is legal for adults aged 21 and over, permitting possession of up to 28.5 grams and cultivation of up to six plants for personal use. The state's legal framework ensures regulated sales and distribution through licensed dispensaries, subject to taxation. However, public consumption and the sale to minors remain illegal, with strict penalties enforced.

While recreational use is permitted, marijuana remains prohibited in certain locations such as schools and public places. California employers maintain the right to enforce drug-free workplace policies, including testing for marijuana, despite its legal status. This balancing act between individual rights and organizational policies reflects California's nuanced approach to marijuana regulation.

California Drug Resources

SAMHSA
Federal resource for substance abuse support and resources.

CDC Drug Overdose
Information on drug overdose prevention and statistics.

DLSE
California's guidelines on workplace drug testing laws.

Drug Policy Alliance
Advocates for drug policies grounded in science, compassion.

NCADD
Provides resources on addiction prevention and recovery.

CA Employers Association
Support for California employers on legal compliance.

Council on Recovery
Offers resources and support for substance abuse recovery.

Drug Court
Combats drug-related offenses through structured program.

HRCI
Credentialing for human resource management and support.

Drug Court Claremont
Local drug court resource supporting rehabilitation efforts.

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