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Accredited Drug Testing delivers complete drug and alcohol examination services across our 40 testing facilities located in Lewisville, Texas, and its surrounding areas. We cater to both DOT and non-DOT requirements with urine drug screenings, breath alcohol analyses, EtG alcohol checks, and comprehensive hair drug testing suitable for individuals, businesses, and legal purposes. We offer quick results and SAMSA-approved lab assessments in Lewisville, TX, ensuring same-day service. Most testing centers are conveniently located just minutes from your home or workspace. Additional offerings include Occupational Health Testing, Clinical Testing, and Background Verification Checks.
To schedule, call (800) 221-4291 or register online. Choose your desired test and select a nearby facility—testing can be arranged for personal, employee, or third-party use. Our scheduling system is designed to be fast and hassle-free, with the option to contact our team or set up appointments online at any time. Our efficient and user-friendly system simplifies arranging screenings near Lewisville.
* You must register by phone or online to receive your donor pass/registration prior to proceeding to the testing center. You must bring a valid government issued ID along with the registration/barcode number which was sent to you by email.
When you're searching for drug testing near me or drug testing locations, we provide a simple and convenient process to find a drug and alcohol testing location near you that is certified to provide all of your drug and alcohol testing needs.
At our Lewisville drug testing collection sites, Accredited Drug Testing provides one of the widest selections of drug and alcohol testing services available. Whether you're an employer, attorney, court, or private individual, we offer both DOT and non-DOT testing options—ranging from rapid tests to comprehensive lab-based screenings—capable of detecting nearly any substance.
DOT Drug Testing and Requirements
DOT Employer Drug Policy Development
If you're an employer needing to test 25 or more employees and looking to save time and money, we offer mobile on-site drug testing where we come to you. Call us today for more information.
In Lewisville, located in Denton County, 15% of adults reported illicit drug use in the past year.
Lewisville, TX has seen a 20% increase in opioid-related deaths in the past three years.
In Denton County, there were 245 drug-related emergency room visits last year.
Lewisville Police reported a 30% rise in drug trafficking arrests over the past two years.
Denton County reported a 17% higher rate of prescription drug misuse compared to the state average.
20% of high school students in Lewisville ISD have tried marijuana at least once.
Drug elimination is the sum of the processes of removing an administered drug from the body. In the pharmacokinetic ADME scheme (absorption, distribution, metabolism, and excretion), it is frequently considered to encompass both metabolism and excretion. Hydrophobic drugs, to be excreted, must undergo metabolic modification making them more polar. Hydrophilic drugs, on the other hand, can undergo excretion directly, without the need for metabolic changes to their molecular structures.
Although many sites of metabolism and excretion exist, the chief organ of metabolism is the liver, while the organ primarily tasked with excretion is the kidney. Any significant dysfunction in either organ can result in the accumulation of the drug or its metabolites in toxic concentrations.
A variety of other factors impact elimination — intrinsic drug properties, such as polarity, size, or pKa. Also other factors include genetic variation among individuals, disease states affecting other organs, and pathways involved in the way the drug distributes through the body, such as first-pass metabolism.
Drug elimination is the removal of an administered drug from the body. It is accomplished in two ways, either by excretion of an unmetabolized drug in its intact form or by metabolic biotransformation followed by excretion. While excretion is primarily carried out by the kidneys, other organ systems are involved as well. Similarly, the liver is the primary site of biotransformation, yet extrahepatic metabolism takes place in a variety of organ systems affecting multiple drugs.
Given the multiple organ systems and the variety of metabolic transformations present, drug elimination can entail a significant degree of complexity. Hydrophilic drugs are typically directly excreted by the kidneys, while hydrophobic drugs undergo biotransformation before excretion. The purpose here is twofold – biotransformation serves both detoxify the exogenous substances as well as to increase their hydrophilicity, ensuring their elimination via the kidneys.
Two broad metabolic pathways of hepatic drug transformation exist. Phase I is the direct modification of the target molecule, whereas phase II entails conjugation of the target to a polar molecule of low molecular weight. Phase I prepare the drug to enter phase II, but single-phase metabolism also exists.
Phase I involves oxidation, reduction, and hydrolysis of the exogenous molecule. These reactions are accomplished by hepatic microsomal enzymes, which reside in the smooth endoplasmic reticulum of the hepatocytes. Best known among them is the cytochrome P450 system, whose enzymes are predominantly involved in oxidative metabolism. Within the cytochrome P450 family (CYP), the enzyme responsible for the metabolism of more than 50% of existing drugs is the CYP3A4. Its activity encompasses various classes of medications, including opioids, immunosuppressants, antihistamines, and benzodiazepines. The enzymes can also be induced or inhibited by a variety of substances they interact with, including pharmaceuticals. The increase in metabolic activity with CYP induction results in a diminished activity of drugs targeted by that particular isoform. Conversely, CYP inhibition will result in increased drug plasma concentration, potentially leading toxicity. The CYP3A4 is induced by phenytoin, phenobarbital, and St. John's wort, while diltiazem, erythromycin, and grapefruit inhibit it. Caution is, therefore, necessary when administering CYP3A4-metabolized drugs in the presence of any of the inhibitors or inducers.
Phase II consists of covalent bonding of polar groups to nonpolar molecules to render them water-soluble and allow renal or biliary excretion. Target molecules enter phase II directly or via initial processing through phase I. A variety of polar adjuncts is transferred, including amino acids, glucuronic acid, glutathione, acetate, and sulfate. Glucuronidation is one of the major pathways of phase II biotransformation. The UDP-glucuronosyltransferase (UGT) enzyme family performs this activity. Typically, glucuronide derivatives possess less or no activity of the original drug, but in some cases, pharmacologically active compounds result. Morphine-6-glucuronide is a phase II metabolite of morphine with significant analgesic activity. As with the CYP enzymes, inducers, and inhibitors of phase II, enzymes exist and may influence the efficacy of drugs that rely on conjugation before excretion.
The first-pass effect is a feature of hepatic metabolism that also plays a role in the elimination of multiple drugs. Here, the enteric consumed drugs are exposed directly to the liver via the portal vein, where they undergo biotransformation before entering the systemic circulation. This activity reduces the bioavailability and needs to be factored into the dose administered to the patient. Intravenously administered drugs are not subject to the first-pass effect.
Extrahepatic drug metabolism takes place in the GI tract, kidneys, lungs, plasma, and skin.
Renal excretion completes the process of elimination that begins in the liver. Polar drugs or their metabolites get filtered in the kidneys and typically do not undergo reabsorption. They subsequently get excreted in the urine. Urinary pH has a significant impact on excretion, as drug ionization changes depending on the alkaline or acidic environment. Increased excretion occurs with weakly acidic drugs in basic urine and weakly basic drugs in acidic urine.
Excretion in the bile is another significant form of drug elimination. The liver can actively secrete ionized drugs with a molecular weight greater than 300 g/mol into bile, from where they reach the digestive tract and are either eliminated in feces or reabsorbed as part of the enterohepatic cycle.
Other pathways of excretion include the lungs, breast milk, sweat, saliva, and tears
Lewisville employers are committed to maintaining a drug-free workplace to ensure safety and productivity. Most local companies adhere to Drug-Free Workplace policies supported by the Office of Drug & Alcohol Policy & Compliance.
In compliance with state guidelines, many employers in Lewisville, TX, implement pre-employment and random drug testing, with resources and guidance available through the Texas Workforce Commission.
By promoting awareness and providing educational resources, employers aim to reduce workplace accidents related to substance abuse, thereby improving overall safety and productivity.
Lewisville, TX, in Denton County, is actively engaging with federal and local agencies to combat drug abuse. Initiatives include increased funding for rehabilitation programs and enhanced law enforcement task forces. More information is available on the Denton County Behavioral Health Leadership Team website.
The local government collaborates with the Substance Abuse and Mental Health Services Administration (SAMHSA) to provide counseling and educational resources, focusing on prevention and recovery strategies specifically tailored for Lewisville's community needs.
In recent years, Lewisville, TX, has experienced several significant drug busts, highlighting the ongoing battle against drug trafficking in Denton County. Police efforts have led to the seizure of large quantities of illicit drugs, including methamphetamines and opioids.
Periodic drug raids conducted by local law enforcement have targeted known hot spots within Lewisville, resulting in numerous arrests and disrupting distribution chains. These operations often involve collaboration with regional narcotics units and federal agencies.
The city organizes educational events and public forums to raise awareness about the dangers of drug abuse. These efforts aim to engage the community and prevent future drug-related incidents.
Accredited Drug Testing offers fast, reliable employment screening services in Lewisville, TX. Trusted by employers nationwide for accurate results and exceptional service.
Texas Department of State Health Services
Recovery Resource Council
Substance Abuse Group of Texas Coalitions
North Central Texas Trauma Regional Advisory Council (NCTTRAC)
Lewisville Police Department
Denton County Health Services
TWogether in Texas
Lewisville ISD Counseling and Social Work
Texas Health and Human Services
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Fast service and friendly staff! Could not recommend enough for drug testing services.
Habib Malik - 4/12/2025
Fast and efficient service for employers wanting to do pre employment drug screening that meets DOT requirements!!
Mary Thomas - 4/5/2025
They are very quick to assist with your orders and they helped when I needed to find a new testing facility.
Gary Matkin - 2/19/2025